Friday, October 1, 2010

Conventional Weight Loss

Conventional wisdom while conventional might not always be wise. Were constantly being told that exercise and weight loss is the way to a healthier life. The research that we seek out or are directed to discover is when the research is correct and how that research is reported incorrectly. The founders wife asked us to look into a report that people with type 2 diabetes didn't have to exercise to loss weight. Our kind of story. That's not what we found. Instead we found that "Intensive lifestyle intervention can produce sustained weight loss" which is the traditional party line. Exercise and lose weight - there is no other way that takes it off and keeps it off according to the four (4) year study. We did find this information.
"Lower Fat Diet in Diabetes - There are today three distinct views concerning the proper diet in diabetes. One group of workers believes that carbohydrates should be kept at a point believed to represent glucose tolerance of the patient. The second group advocates a high fat, non-ketogenic low carbohydrate diet. The third group, holding the most recent views, advocates what seems like a very high carbohydrate and low fat diet. All agree upon the desirability of avoiding ketosis, meeting caloric needs and supplying the patient with a physiologic diet. - Annals of Internal Medicine (December 1930)
Conventional wisdom from the best minds of their time. To that end we offer you this latest information from the best minds of our time. Think of information and research as more round earth theory than flat earth theory. We think that if you're still alive at the end of the day you're ahead of the game. This doesn't mean that we think that the idea of exercising to lose weight is a flat earth theory we don't.  We can hope and pray but we know that that won't necessarily make it so.
"Low-Carbohydrate Diets and All-Cause and Cause-Specific Mortality - A low-carbohydrate diet based on animal sources was associated with higher all-cause mortality in both men and women, whereas a vegetable-based low-carbohydrate diet was associated with lower all-cause and cardiovascular disease mortality rates." - Annals of Internal Medicine (September 2010
What a difference twenty-three (23) years and over one hundred twenty-nine thousand seven hundred and sixteen (129,716) people later. We know more today than we did eighty (80) years ago. We know more or do we? The research numbers are difficult to dispute when they're so large and comprise two (2) studies and not one (1). What a difference a millennium and computers make.
"...a doctors group seeks to compel the agency to alert patients to safe dietary alternatives to Avandia and other diabetes drugs that may increase the risk of stroke, heart failure, and death. The nonprofit Physicians Committee for Responsible Medicine (PCRM) is filing the suit in the U.S. District Court for the District of Columbia. The lawsuit targets FDA commissioner Margaret Hamburg, M.D., for failing to act on a PCRM administrative petition urging the FDA to require that diabetes drugs carry warning labels telling patients that low-fat plant-based diets can effectively treat type 2 diabetes without dangerous side effects associated with oral medications." - Physicians Committee for Responsible Medicine (PCRM) July 2010 
When we reported on the pine bark extract research were news reports cited its supposed ineffectiveness we call your attention to Food and Drug Administration (FDA) approved drugs that are dangerous and deadly rather than possible useless. We maintain that while the Japanese pine bark extract might have been useless in the application tested that misuse of any medication generally renders it ineffective.
"AVANDIA may increase the risk of heart problems related to reduced blood flow to the heart. These include possible increases in the risk of heart-related chest pain (angina) or "heart attack" (myocardial infarction). This risk seems to be higher in patients who took AVANDIA with insulin or with nitrate medicines. Most people who take insulin or nitrate medicines should not also take AVANDIA. If you have chest pain or a feeling of chest pressure, get medical help right away, no matter what diabetes medicines you are taking. Patients with diabetes have a greater risk for heart problems. It is important to work with your doctor to manage other conditions, such as high blood pressure or high cholesterol." FDA (February 2008
We reported on the complaint that the Food and Drug Administration (FDA) had against POM the "pomegranates and pomegranate-based products" company and we were against it. We support the FDA in it's efforts to protect "the public health" we just think that going after this one privately held company isn't necessarily in that interest. We could be wrong and POM might have been asking for it since they did sue Minute Maid. Not that there's anything wrong with it! We just don't like lawsuits.
"Protecting the food supply, making it safe, making it nutritious, is one of the most fundamental duties of government," says Michael R. Taylor, Deputy Commissioner for Foods at the FDA. He explains that for a hundred years the public has really depended upon FDA to prevent foods from being contaminated and to set standards for labeling foods to help people know what they are buying and hopefully choose healthy diets. But the Office of Foods, created in 2009, came into being as a response to new challenges involving the food supply. The new emphasis, says Taylor, is on implementing "common sense measures" to prevent problems before they occur." - FDA Basic Video (Food Safety and Nutrition
You can watch the video of DC Michael R. Taylor in his own words describing the Food and Drug Administration's position and purpose. The FDA is the last line of federal defense against hucksters and snake oil salesmen that seek to separate you from your money and can endanger your health. We worry like the PCRM agency gives too much levy way to big businesses at the expense of the individual. Not always and not as a matter of policy. Sometimes lives are put at risk and when they are we're here to say: "Don't Do It!" If and when necessary - which we presume will be few and far between. Mostly we're here to say don't wait for the dead and dying.
"24-Week Phase 3 Study Found Investigational Drug Dapagliflozin Improved Glycosylated Hemoglobin (HbA1c) When Added to Glimepiride in Adults with Type 2 Diabetes Mellitus - The study also demonstrated that dapagliflozin plus glimepiride achieved reductions in the secondary efficacy endpoints of change in total body weight, oral glucose tolerance test (OGTT) and fasting plasma glucose (FPG) levels from baseline at week 24 compared to placebo plus glimepiride." - AstraZeneca (September 20, 2010
Okay this is awkward. We've said what we said and then we drop this bit of news on you. So let's just say it now. That the preceding statement has little to do with the aforementioned quotation. It's just where it fit into the story. We will however include both good news and bad news about the "less exercising better results" product simply as a matter of information. We aren't making any judgments on the product. Twenty-four (24) weeks and almost six hundred (597) patients discovered that "dapagliflozin plus glimepiride" achieved reductions and this is an amazing research revelation revealed at the European Association for the Study of Diabetes in Stockholm this week. Now if someone decides to test the new drug WITHOUT glimepiride which should result in no reductions that will mean it's ineffective. Unlike pine bark extract which is relatively harmless while the new drug dapagliflozin is anything but harmless.
"New Diabetes Drug Dapagliflozin Closer to Approval - Generally, the occurrence of side effects was about equal across all four groups. Rates of genital infections were higher among patients treated with dapagliflozin than those taking placebo, but the infections were mild and did not cause any patients to withdraw from the trial." - Emax Health (October 2009
We are not anti-perscription drug. Remember what we said earlier. If you're still alive at the end of the day you're ahead of the game. We want you ahead - not dead. Food and Drug Administration (FDA) approved drugs can put your tomorrows at risk. Sometimes this federal organization has to be forced by lawsuit to do what's best for you and we. Given the choice of treatment between Dapagliflozin, pine bark extract or bariatric (weight loss surgery) operations we'd choose the first two (2) rather than the latter.
"Risk of Suicide after Long-term Follow-up from Bariatric Surgery - Compared with age and sex-matched suicide rates in the US, there was a substantial excess of suicides among all patients who had bariatric surgery in Pennsylvania during a 10-year period. These data document a need to develop more comprehensive longer-term surveillance and follow-up methods in order to evaluate factors associated with postbariatric surgery suicide." - The American Journal of Medicine (September 2010
Weight loss surgery might seem to be the easiest solution to the problem of obesity because you just lie back and let the surgeons cut away while dreaming dreams of sweetness and light. You awaken and hopefully be lighter while feeling so much better ignoring the ugly scars that indicate the procedure. There's a real couch potato feeling to it with one research demonstrated downfall. It could be that Pennsylvanians are more susceptible than other citizens but when the surgeries are in excess of sixteen thousand (16,683) the numbers are difficult to dispute or ignore.

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