Aspirin Prevents Bowel Cancer

We've always supported the use of aspirin and we've also spoken on how scientific research can be misused to mislead and aspirin was our example. Aspirin has been found to be successful for reducing heart damage or high blood pressure but not heart attacks, and now cancer of the colon. Aspirin has not been found effect in stopping stab wounds or automobile accidents. It's not meant to. Research into such things would not be useful except to disparage or discourage aspirin use. It's affordable, available and well tested.

"Aspirin taken for several years at doses of at least 75 mg daily reduced long-term incidence and mortality due to colorectal cancer. Benefit was greatest for cancers of the proximal colon, which are not otherwise prevented effectively by screening with sigmoidoscopy or colonoscopy." - The LANCET (Interpretation)

We also spoken on the amount used. In the recently release study more aspirin has been more effective. In the past we talked about governments recommend use levels but also the effects and concerns of toxicity in exceeding recommended amounts. Indeed in the studies the researchers spoke on this very issue of the twenty (20) year over fourteen thousand (14,032) Brits, Dutch, and Sweds participants:

"High-dose aspirin (≥500 mg daily) reduces long-term incidence of colorectal cancer, but adverse effects might limit its potential for long-term prevention. The long-term effectiveness of lower doses (75—300 mg daily) is unknown. We assessed the effects of aspirin on incidence and mortality due to colorectal cancer in relation to dose, duration of treatment, and site of tumour." - The LANCET (Background)

We know its more of a review of one specific study on the power of the aspirin. Aspirin works and if you're concerned about colorectal cancer you might want to add it to your medical regime if you FIRST discuss your intention with your primary care physician. According to the current research in the British Journal THE LANCET. So we do mention the publication in some of our stories but there is a caveat. Well there is now. The World Health Organization (WHO) finds some flaws with the publication:

"WHO disputes Lancet's report on number of malaria deaths in India - The World Health Organization has disputed the findings of a study on malaria that claimed the number of Indians dying from the mosquito-borne disease each year 13 times higher than the United Nations health agency's estimate. The study was published in the British medical journal Lancet. The research claimed that malaria causes 200,000 deaths in India every year. However, the WHO estimates that 15,000 malarial deaths take place each year in India." - OneIndia (ANI)

We don't often quote OneIndia either. We do so to say that the review of the review shouldn't be considered the final word on the subject. Neither we nor the Lancet are the final words on the matter. Aspirin - GOOD. Bowel cancer - BAD. The final word on the subject may come from the ASPirin in Reducing Events in the Elderly (ASPREEE) international study.

"This research study is the largest international trial ever funded by the National Institute on Aging (NIA), and is being conducted in partnership with over 21 clinics and universities across the United States." - ASPREE (English Brochure)

While the study won't really affect or apply to us (God willing and the creek don't rise) if we live to a ripe old age the results might be useful to us. Prior research has already demonstrated the success of aspirin and taking a low dose a day has shown to be more useful than not. What the study doesn't do that we have concerns with is that it doesn't appear to be focusing on interactions among the elderly. We know of no cases where seniors are NOT on multiple medications. Nor do we support giving any senior a placebo for five (5) years when aspirin has proven to be so effective.

"Women's Health Study Researchers Publish Landmark Findings - Nancy Cook, ScD served as the lead investigator on the low-dose aspirin and cancer analyses, and I-Min Lee, MBBS, ScD was the lead investigator of the vitamin E and cardiovascular and cancer analyses. “As a result of our findings, we do not suggest doctors recommend low-dose aspirin therapy for primary prevention of cancer,” Cook said. WHS analyses could not rule out benefits of higher doses of aspirin, and Cook and her colleagues recommend additional study. Lee's analyses debunked a common misconception that vitamin E helps prevent cardiovascular disease or cancer in healthy women. “At present, a healthy lifestyle and regular screening for cardiovascular health and cancer are a woman's best choices for disease prevention,” she said. The study, however, did show that vitamin E reduced cardiovascular mortality rates, a finding that is not consistent with data from other studies prompting WHS researchers to recommend additional exploration." - BWH Bulletin (July 15, 2005)

The study contradicts the American research from Brigham and Women's Hospital (BWH) in Boston. The twelve (12) year forty-thousand (40,000) women study. Except it doesn't. The BWH Women's Health Study (WHS) concerns low dose aspirin and "breast, colorectal and other site-specific cancers." The results from that study which included the use of Vitamin E and cancer. It's the contradictions in the findings that makes the study so interesting. Vitamin E doesn't work says the researchers.

"Lee's analyses debunked a common misconception that vitamin E helps prevent cardiovascular disease or cancer in healthy women. “At present, a healthy lifestyle and regular screening for cardiovascular health and cancer are a woman's best choices for disease prevention,” she said. The study, however, did show that vitamin E reduced cardiovascular mortality rates, a finding that is not consistent with data from other studies prompting WHS researchers to recommend additional exploration." - BWH Bulletin (July 15, 2005)

I-Min Lee is, in our humble opinion, wrong. The research says the researchers are wrong. Rather, the research indicates that its not completely correct in their assessment. While vitamin E and aspirin do NOT prevent cancer or disease. Yet, if we take aspirin and vitamin E we won't be among those numbers of the dead and dying that do not. Research shows that as well.

HPV Hope and Help

What finally beat PearlieMae and many of our relatives was the dreaded "C" word (cancer). It was their generation's AIDS and struck more fear and hopelessness in them than any other condition. For them and their peers it was a sentence of death. It didn't matter how many therapies, protocols or alternative treatments there were. It meant they were going to die. Indeed in spite of the fact that her doctors didn't expect her to respond to treatment PearlieMae did. She could have survived her cancer. It would not have meant she would have been cured but she would not have had to die from the ravages of the disease. PearlieMae surrendered to her illness. She gave up hope and that's what killed her.

While the debate continues concerning the cervical cancer vaccine for teenage girls and young adults some researchers are suggesting is that as hopeful as this treatment is it isn't the be all end all cure that many would believe especially for the teenage future PearlieMaes.

"...excess of 18,000 adverse reactions recorded in the US, including 75 deaths. Adverse reactions have also been recorded in New Zealand, Canada and Australia. A US federal report in 2009 found the vaccine had a 400% higher rate of adverse reactions than another comparable vaccine, the Menactra anti-meningitis shot. The Irish Medicines Board (IMB) said it had received 10 reports of suspected adverse reactions associated with Gardasil." (Irish Examiner)

Hope springs eternal - while we know the cervix isn't a bone and PearlieMae's cancer wasn't cervical it made it into her back and into her bones. The same institution that is developing a more effective vaccine than Gardasil which only works against four (4) types of HPV (human papillomavirus) and Cervarix which only works against five (5) types with a vaccine that works against nine (9) types of the cancer. Extending the effectiveness from eighty (80) percent to ninety (90) percent effectiveness and essentially reducing the possibility of adverse reactions.

"Cancer has a greater economic impact from premature death and disability than all causes of death worldwide, according to a report from the American Cancer Society (ACS) and the LIVESTRONG organization. Using data from the World Health Organization (WHO), it concludes that cancer "has the most devastating economic impact of any cause of death in the world." (Medscape Today)

The Medical College of Georgia (MCG) has also identified a protein that can result in fragile bones. While PearlieMae's cancer cause her bones to be brittle and hindsight is 20/20 we believe that had she not been so depressed by her virus she might have survived to live a longer life and suffered a more prolonged death. Of course we would believe this because we miss her so much and love her so. We loved her enough to concede to her wishes to not prolong her death.

"In late-stage arthritis, the cartilage function may be completely disrupted but early in the disease process, maybe there is a window for stimulating this protein." (MCG)

Family members that haven't told their own parental units are terrified of their condition even though when discovered in the early stages treatment can be very effective. That's not just our opinion it's also the opinion of specialist in the field.

"If cervical cancer is caught very early, surgery alone may effect a cure. If the disease is more extensive, then radiation is added to the treatment mix... ...Patients with cervical cancer and, in some cases, uterine cancer first get external beam radiation under the new large bore linear accelerator at the Georgia Radiation Therapy Center. This first phase of radiation treatment lasts about five to five-and-a-half weeks. - Dr. Chris Sheils (MCG)

Yes, we're big on prevention but actionable prevention like eating dark non-milk chocolate, adding deep colored foods to your diet - the easy stuff. We even support the taking of vaccines to prevent an annual massacre. But you have to compare the upside to down and make the judgment yourself. We just want to make sure that the treatment isn't as bad as the cure.

So sweet relative of ours, please tell your momma - there is hope and you will survive.

Simply Not The Best

Our concern is that all of us in business and in life don't always do our best. We're really critical of ourselves and we often admit to slot and inactivity knowing that there is better way of living. What made "this country great" has always been our drive to do better - together - rich helping poor, healthy helping infirmed, strong helping weak. That's the American way - united we stand. Whether that was in achievements, inventions or families we strive to go beyond what we've done before to what we can do today.

"Nations, like men, often march to the beat of different drummers, and the precise solutions of the United States can neither be dictated nor transplanted to others. What is important is that all nations must march toward a increasing freedom; toward justice for all; toward a society strong and flexible enough to meet the demands of all of its own people, and a world of immense and dizzying change." - Robert F. Kennedy

The headlines from CNN - Women's health an 'urgent priority', The Associated Press (AP) and the U.S. News & World Report highlighted AIDS, only TIME trumpeted - Why Sexism Kills. While the original World Health Organization (WHO) press releases stated: "WHO calls for action beyond the health sector to improve the health of girls and women" -

• Despite progress, societies continue to fail women at key times
• Women provide the bulk of health care, but rarely receive the care they need
• Women live longer than men but these extra years are not always healthy
• Despite some biological advantages, women's health suffers from their lower socio-economic status
• Policy change and action is needed within the health sector and beyond

It's easy for this nation to ignore the world when it tries to lead and direct what was usually our domain. The United States is the world leader and we set the pace for the rest to follow. We're not use to taking orders the same way PearlieMae's not use to doing what we need to do to take care of ourselves. However when it's our loved ones there is nothing we won't do to make them safe, healthy and better.

I'll pray for you, you pray for me
I love you
I need you to survive
I won't harm you
With words from my mouth
I love you
I need you to survive - David G. Frasier(View)(Listen)

Have a wonderful Veteran's Day. If you have a vet in your life, write, call, email send love in any and every way you can. If you are a Vet - we salute you! Thank you. Thank you. Thank you!